articleTop 10% cited
Rate-Limited Steps of Human Oral Absorption and QSAR Studies
Pharmaceutical Research · 2002 · Vol. 19(10) · pp. 1446–1457
Yuan H. Zhao✉(University College London)Michael H. Abraham(University College London)Joelle Le(University College London)Anne Hersey(GlaxoSmithKline (United Kingdom))Chris Luscombe(GlaxoSmithKline (United Kingdom))Gordon Beck(Roche (United Kingdom))Brad Sherborne(Roche (United Kingdom))Ian Cooper(Roche (United Kingdom))
Crystallization and Solubility StudiesAnalytical Chemistry and ChromatographyDrug Solubulity and Delivery SystemsBiopharmaceutics Classification SystemSolubilityChemistryDissolutionAbsorption (acoustics)BiopharmaceuticsPolar surface areaKineticsChromatographyMaterials science
MeSH terms
Administration, OralPharmaceutical PreparationsHumansIntestinal AbsorptionRegression AnalysisQuantitative Structure-Activity Relationship
Citations
702
FWCI
3.40
field-weighted impact
References
28
Percentile
92%
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Citations per year
References
Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans
Pharmaceutical Research · 1997 · 746 citations
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Advanced Drug Delivery Reviews · 2001 · 17,620 citations
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors
Journal of Pharmaceutical Sciences · 2001 · 517 citations
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