articleTop 1% cited

Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans

Pharmaceutical Research · 1997 · Vol. 14(5) · pp. 568–571

Katrin Palm✉(Uppsala University)Patric Stenberg(Uppsala University)Kristina Luthman(Uppsala University)Per Artursson(Uppsala University)

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Computational Drug Discovery Methods Analytical Chemistry and Chromatography Lipid Membrane Structure and BehaviorPolar surface areaAbsorption (acoustics)ChemistryPharmacologyStereochemistryBiophysicsMedicineMaterials scienceBiologyMolecule

MeSH terms

Chemistry, PharmaceuticalChemistry, PhysicalPharmaceutical PreparationsHumansHydrogen BondingIntestinal AbsorptionModels, TheoreticalPermeabilitySolubilitySurface PropertiesChemical Phenomena

Citations

746

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30.52

field-weighted impact

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References

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Biochemical and Biophysical Research Communications · 1991 · 1,852 citations

Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

Journal of Computational Chemistry · 1990 · 3,754 citations

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