articleTop 10% cited
In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth
Pharmaceutical Research · 1997 · Vol. 14(6) · pp. 763–766
Shiyin Yee✉(Pfizer (United States))
Drug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesAdvanced Drug Delivery SystemsParacellular transportTranscellularCaco-2In vivoChemistryAbsorption (acoustics)In vitroMembraneMonolayerBiophysics
MeSH terms
Biological TransportCell Membrane PermeabilityPharmaceutical PreparationsHumansIntestinal AbsorptionIntestine, SmallCaco-2 Cells
Citations
1,012
FWCI
6.45
field-weighted impact
References
15
Percentile
97%
vs. same field & year
Citations per year
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References
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
Biochemical and Biophysical Research Communications · 1991 · 1,852 citations
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