reviewTop 1% cited

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Trends in Biochemical Sciences · 2010 · Vol. 35(9) · pp. 505–513

Robert B. Hamanaka(Northwestern University)Navdeep S. Chandel✉(Northwestern University)

Mitochondrial Function and Pathology Neutrophil, Myeloperoxidase and Oxidative Mechanisms Redox biology and oxidative stressReactive oxygen speciesCell biologyMitochondrionOxidative stressSignal transductionCell signalingBiologyMitochondrial ROSBiochemistry

MeSH terms

AnimalsCell Physiological PhenomenaHumansMitochondriaSignal TransductionReactive Oxygen Species

Funding

National Institutes of Health

Citations

974

FWCI

25.15

field-weighted impact

References

103

Percentile

100%

vs. same field & year

Citations per year

Cited by

ROS production in phagocytes: why, when, and where?

Journal of Leukocyte Biology · 2013 · 452 citations

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

eLife · 2014 · 1,094 citations

Regulation of autophagy by ROS: physiology and pathology

Trends in Biochemical Sciences · 2010 · 1,243 citations

Mitochondrial Dysfunction in Cancer

Frontiers in Oncology · 2013 · 509 citations

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

Free Radical Biology and Medicine · 2016 · 1,000 citations

From Krebs to clinic: glutamine metabolism to cancer therapy

Nature reviews. Cancer · 2016 · 2,092 citations

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

Journal of Cellular Physiology · 2016 · 677 citations

Mitochondrial uncoupling, ROS generation and cardioprotection

Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2018 · 577 citations

References

Biology of HIF-1α

Cell Death and Differentiation · 2008 · 914 citations

Superoxide Dismutase

Journal of Biological Chemistry · 1969 · 12,768 citations

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Nature Reviews Drug Discovery · 2009 · 5,229 citations

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

Molecular Cell · 2008 · 3,185 citations

Physiological and Pathological Responses to Hypoxia

American Journal Of Pathology · 2004 · 562 citations

Persistent oxidative stress in cancer

FEBS Letters · 1995 · 1,215 citations

Biochemistry and molecular cell biology of diabetic complications

Nature · 2001 · 8,964 citations

Mitochondrial formation of reactive oxygen species

The Journal of Physiology · 2003 · 3,946 citations

Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress

Frontiers in Physiology · 2021 · 368 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.