In vivo study of oxidative effect of aspirin nanoparticles in rat blood samples utilizing electrochemical analysis by cyclic voltammetry

Abstract

The application of nanotechnology in pharmaceutical applications has opened new avenues for improving bioavailability and therapeutic efficacy. Aspirin Nanoparticles (ASP-NPs) improve pharmacokinetic properties, and their oxidative effects on biological systems are investigated in this research. This biochemical study explores the oxidative behavior of aspirin nanoparticles in rat blood samples using electrochemical techniques, specifically Cyclic Voltammetry (CV). The results show significant changes in the redox peaks, indicating that the oxidative stress in the blood was reduced by the use of aspirin nanoparticles. These results provide insights into the safety and redox behavior of nanoparticle-based drug formulations, particularly their effects on blood and the gastrointestinal tract. The study focused on the behavior of nano-aspirin on rat blood composition using cyclic voltammetry at various pHs and temperatures.