Anti-diabetic and anti-inflammatory activity of different metabolites extracted from Mesua ferrea using chromatographic techniques

Abstract

Overuse of antimicrobial drugs has led to selective resistance to existing antibiotics, necessitating the development of different and improved alternatives. Natural substances, particularly those derived from plants, are well-known for their therapeutic characteristics, including antibacterial and antifungal properties. The main objective of the present study was to evaluate the anti-inflammatory activity of isolated bioactive flavonoid Mesua ferrea in-A from the bark of Mesua ferrea L. by in vivo approach. The Alpha Amylase Inhibition Assay was used to assess antidiabetic effectiveness in vitro. Fractions 3 and 5 displayed the most activity. Using reducing power, an antioxidant activity test was performed. Fraction no. 3 showed a higher absorbance of 0.94 at 500 g/ml.