reviewTop 1% cited
ADMET in silico modelling: towards prediction paradise?
Nature Reviews Drug Discovery · 2003 · Vol. 2(3) · pp. 192–204
H. Van De Waterbeemd✉(Pfizer (United Kingdom))Eric Gifford(Pfizer (United States))
Computational Drug Discovery MethodsPharmacogenetics and Drug MetabolismAnalytical Chemistry and ChromatographyADMEIn silicoDrug discoveryPharmacokineticsComputational biologyDrug developmentDrugHigh-throughput screeningPharmacologyComputer science
MeSH terms
AnimalsBiological AvailabilityBlood-Brain BarrierChemistry, PhysicalComputer SimulationHumansModels, BiologicalPharmacokineticsProtein BindingSoftwareTissue DistributionDrug DesignQuantitative Structure-Activity RelationshipChemical PhenomenaDrug-Related Side Effects and Adverse Reactions
Citations
1,819
FWCI
60.50
field-weighted impact
References
108
Percentile
100%
vs. same field & year
Citations per year
Cited by
Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective
Clinical Pharmacology & Therapeutics · 2015 · 466 citations
A Bioavailability Score
Journal of Medicinal Chemistry · 2005 · 963 citations
The influence of drug-like concepts on decision-making in medicinal chemistry
Nature Reviews Drug Discovery · 2007 · 2,269 citations
Calculation of Molecular Lipophilicity: State-of-the-Art and Comparison of LogP Methods on more than 96,000 Compounds
Journal of Pharmaceutical Sciences · 2008 · 646 citations
Designing antimicrobial peptides: form follows function
Nature Reviews Drug Discovery · 2011 · 1,976 citations
Docking and scoring in virtual screening for drug discovery: methods and applications
Nature Reviews Drug Discovery · 2004 · 3,899 citations
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
Journal of Medicinal Chemistry · 2015 · 5,075 citations
References
Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties
Journal of Medicinal Chemistry · 2000 · 2,969 citations
Predicting plasma protein binding of drugs: a new approach
Biochemical Pharmacology · 2002 · 545 citations
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
Journal of Pharmaceutical Sciences · 1999 · 611 citations
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
Journal of Medicinal Chemistry · 2002 · 7,875 citations
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood–brain barrier penetration
Journal of Pharmaceutical Sciences · 1999 · 511 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Advanced Drug Delivery Reviews · 2001 · 17,620 citations
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors
Journal of Pharmaceutical Sciences · 2001 · 517 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Advanced Drug Delivery Reviews · 1997 · 11,043 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.