articleTop 10% cited
Predicting plasma protein binding of drugs: a new approach
Biochemical Pharmacology · 2002 · Vol. 64(9) · pp. 1355–1374
Nicole A. Kratochwil✉(Roche (Switzerland))Walter Huber(Roche (Switzerland))Francis Müller(Roche (Switzerland))Manfred Kansy(Roche (Switzerland))Paul R. Gerber(Roche (Switzerland))
Protein Interaction Studies and Fluorescence AnalysisDrug Transport and Resistance MechanismsProtein purification and stabilityLipophilicityChemistryPlasma protein bindingHuman serum albuminBinding siteBlood proteinsQuantitative structure–activity relationshipComputational biologyStereochemistryBiochemistry
MeSH terms
Pharmaceutical PreparationsHumansModels, BiologicalProtein BindingSerum AlbuminStatistics as TopicReproducibility of Results
Citations
545
FWCI
3.08
field-weighted impact
References
219
Percentile
92%
vs. same field & year
Citations per year
Cited by
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
Journal of Medicinal Chemistry · 2008 · 940 citations
ADMET in silico modelling: towards prediction paradise?
Nature Reviews Drug Discovery · 2003 · 1,819 citations
Structural Basis of the Drug-binding Specificity of Human Serum Albumin
Journal of Molecular Biology · 2005 · 1,885 citations
References
The pharmacological basis of therapeutics
American Heart Journal · 1941 · 1,909 citations
Clustering Using a Similarity Measure Based on Shared Near Neighbors
IEEE Transactions on Computers · 1973 · 962 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Advanced Drug Delivery Reviews · 2001 · 17,620 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.