Protective effect of Andrographis paniculata on haematobiochemical profile during chlorpyrifos induced subacute toxicity in Japanese quails

Abstract

The present study evaluated the protective effect of Andrographis paniculata on hematobiochemical profile during chlorpyrifos induced subacute toxicity in quails. Seventy five, two week old broilers quails after acclimatization period of one week were randomly divided into five equal groups. Group I served as control where as group II was treated with chlorpyrifos @ 15 mg/kg in feed. Group III, IV and V were treated with dried leaves powder of Andrographis paniculata @ 5 gm/kg of feed. In addition to dried leaves powder, group IV and V were treated with chlorpyrifos @ 15 mg/kg and 20 mg/kg of feed, respectively. At the end of 4th week of experiment hematobiochemical profiles were recorded. Results indicated significant increase in Hb, PCV and TEC in group II and non significant increase in group IV and V compared to control group. MCV, MCH and MCHC were found to be statistically non-significant. TLC, absolute lymphocyte and neutrophil count showed significant decrease in group II while group IV and V showed significant increase in heterophil and non significant increase in lymphocyte. Serum total protein, albumin and globulin differ non significantly. Serum creatinine, AST, ALT and GGT decreased significantly in group II but group IV and V showed improvement towards control group. It is thus concluded that chlorpyrifos @ 15 mg/kg of feed has adverse effect on haematobiochemical profile but co-administration of dried leaves powder of Andrographis paniculata along with chlorpyrifos @ 15 mg/kg and 20 mg/kg of feed showed dose dependant putative protective effect in Japanese quails.