Effect of Andrographis paniculata on hematobiochemical profile during monensin induced toxicity in Japanese quails

Abstract

The present investigation was carried out to study the ameliorative effect of Andrographis paniculata on hematobiochemical profile during monensin toxicity in Japanese quails. At the end of 28 day quails fed with monensin @ 150 mg/kg of feed showed adverse effect on haematological profile of Hb, PCV, TEC, TLC, heterophil and lymphocyte count, whereas birds given monensin along with dried leaves powder of Andrographis paniculata showed dose dependant (@ 3g/kg and 5 g/ kg feed) beneficial effect. Monensin only toxicated birds showed significant increase in serum AST, creatinine, and phosphorus whereas birds given monensin along with dried leaves powder of Androgrphis paniculata showed significant decreased values and suggested beneficial property of plant during monensin toxicity. Increased serum calcium level in monensin treated birds showed restoration when given Andrographis paniculata along with it. Thus it is concluded that dried leaves powder of Andrographis paniculata showed hematinic, hepatoprotective and renoprotective effect @ 3g/kg and 5 g/ kg feed during monensin sodium toxicity in Japanese quails given @ 150 mg/kg in feed.