The protective effects of Withania somnifera on biochemical profile of hepato-renal and endocrine system in fenvalerate exposed cockerels

Abstract

After acclimatization for a period of one week, a day old 80 cockerels were randomly divided into four equal groups comprising 20 birds in each. Group T1 (control); group T2 was treated with fenvalerate @ 300 mg/kg of feed; group T3 was treated with Withania somnifera @ 200 mg/kg of feed and group T4 was given fenvalerate @ 300 mg/kg of feed with Withania somnifera @ 200 mg/kg of feed for four weeks and withdrawal of treatment for seven days. At 5th week as well as at 6th week serum AST and ALT showed significant (P≤0.05) increase in fenvalerate treated (T2) group while T4 group showed improvement. At the end of 5th week T2 group showed significant (P≤0.05) increase in BUN, creatinine, GGT and cholesterol but significant (P≤0.05) decrease in serum total protein, albumin, globulin, triiodothyronine, thyroxine and triiodothyronine: thyroxine ratio when compared with control and T4 group. From the present results it is concluded that Withania somnifera has protective effects on the various biochemical parameters against fenvalerate toxicity.