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Dexamethasone in Hospitalized Patients with Covid-19

New England Journal of Medicine · 2020 · Vol. 384(8) · pp. 693–704
The RECOVERY Collaborative Group

Abstract

In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support. (Funded by the Medical Research Council and National Institute for Health Research and others; RECOVERY ClinicalTrials.gov number, NCT04381936; ISRCTN number, 50189673.).

COVID-19 Clinical Research StudiesRespiratory Support and MechanismsLong-Term Effects of COVID-19DexamethasoneRandomizationMechanical ventilationRandomized controlled trialClinical trialRespiratory failureRespiratory disease

MeSH terms

COVID-19COVID-19 Drug TreatmentAdministration, OralAgedAged, 80 and overAnti-Infective AgentsDexamethasoneDrug Therapy, CombinationFemaleGlucocorticoidsUnited KingdomHospitalizationHumansInjections, IntravenousLength of Stay

Funding

  • National Institute for Health and Care Research
  • Department of Health and Social Care
  • Public Health England
  • Medical Research Council
  • Biotechnology and Biological Sciences Research Council
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