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Remdesivir for the Treatment of Covid-19 — Final Report

New England Journal of Medicine · 2020 · Vol. 383(19) · pp. 1813–1826

John H. Beigel✉(National Institute of Allergy and Infectious Diseases)Kay M Tomashek(National Institute of Allergy and Infectious Diseases)Lori E. Dodd(National Institute of Allergy and Infectious Diseases)Aneesh K. Mehta(National Institute of Allergy and Infectious Diseases)Barry S. Zingman(National Institute of Allergy and Infectious Diseases)André C. Kalil(National Institute of Allergy and Infectious Diseases)Elizabeth Hohmann(National Institute of Allergy and Infectious Diseases)Helen Y. Chu(National Institute of Allergy and Infectious Diseases)Annie Luetkemeyer(National Institute of Allergy and Infectious Diseases)Susan Kline(National Institute of Allergy and Infectious Diseases)Diego López de Castilla(National Institute of Allergy and Infectious Diseases)Robert W. Finberg(National Institute of Allergy and Infectious Diseases)Kerry Dierberg(National Institute of Allergy and Infectious Diseases)Victor F. Tapson(National Institute of Allergy and Infectious Diseases)Lanny Hsieh(National Institute of Allergy and Infectious Diseases)Thomas F. Patterson(National Institute of Allergy and Infectious Diseases)Roger Paredes(National Institute of Allergy and Infectious Diseases)Daniel A Sweeney(National Institute of Allergy and Infectious Diseases)William R. Short(National Institute of Allergy and Infectious Diseases)Giota Touloumi(National Institute of Allergy and Infectious Diseases)David Chien Lye(National Institute of Allergy and Infectious Diseases)Norio Ohmagari(National Institute of Allergy and Infectious Diseases)Myoung‐don Oh(National Institute of Allergy and Infectious Diseases)Guillermo M. Ruiz‐Palacios(National Institute of Allergy and Infectious Diseases)Thomas Benfield(National Institute of Allergy and Infectious Diseases)Gerd Fätkenheuer(National Institute of Allergy and Infectious Diseases)Mark G. Kortepeter(National Institute of Allergy and Infectious Diseases)Robert L. Atmar(National Institute of Allergy and Infectious Diseases)C. Buddy Creech(National Institute of Allergy and Infectious Diseases)Jens Lundgren(National Institute of Allergy and Infectious Diseases)Abdel G. Babiker(National Institute of Allergy and Infectious Diseases)Sarah Pett(National Institute of Allergy and Infectious Diseases)James D. Neaton(National Institute of Allergy and Infectious Diseases)Timothy Burgess(National Institute of Allergy and Infectious Diseases)Tyler Bonnett(National Institute of Allergy and Infectious Diseases)Michelle Green(National Institute of Allergy and Infectious Diseases)Mat Makowski(National Institute of Allergy and Infectious Diseases)Anu Osinusi(National Institute of Allergy and Infectious Diseases)Seema Nayak(National Institute of Allergy and Infectious Diseases)H. Clifford Lane(National Institute of Allergy and Infectious Diseases)

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Abstract

Our data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection. (Funded by the National Institute of Allergy and Infectious Diseases and others; ACTT-1 ClinicalTrials.gov number, NCT04280705.).

COVID-19 Clinical Research Studies Long-Term Effects of COVID-19 SARS-CoV-2 and COVID-19 ResearchCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyMedicineInternal medicineOutbreak

MeSH terms

BetacoronavirusCOVID-19SARS-CoV-2COVID-19 Drug TreatmentAdenosine MonophosphateAdultAgedAlanineAntiviral AgentsDouble-Blind MethodFemaleHumansMaleMiddle AgedOxygen Inhalation Therapy

Funding

U.S. Department of Defense
U.S. Department of Health and Human Services
U.S. Department of Veterans Affairs
Henry M. Jackson Foundation
Gilead Sciences
Division of Intramural Research, National Institute of Allergy and Infectious Diseases
Northwestern University
University of Pittsburgh
King's College London
Seoul National University
Seoul National University Hospital
Universität Regensburg
National Institutes of Health
Uniformed Services University of the Health Sciences
Feinberg School of Medicine
Medical Research Council
National Cancer Institute
National Institute of Allergy and Infectious Diseases