article Open AccessTop 10% cited
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Nature Structural & Molecular Biology · 2020 · Vol. 27(9) · pp. 846–854
Jiandong Huo✉(Centre for Human Genetics)Audrey Le Bas(Centre for Human Genetics)Reinis R. Ruza(Centre for Human Genetics)Helen M. E. Duyvesteyn(Centre for Human Genetics)Halina Mikolajek(Diamond Light Source)Tomas Malinauskas(Centre for Human Genetics)Tiong Kit Tan(John Radcliffe Hospital)Pramila Rijal(Academy of Medical Sciences)Maud Dumoux(Rosalind Franklin Institute)Philip N. Ward(Centre for Human Genetics)Jingshan Ren(Centre for Human Genetics)Daming Zhou(Centre for Human Genetics)Peter J. Harrison(Centre for Human Genetics)Miriam Weckener(Rosalind Franklin Institute)Daniel K. Clare(Diamond Light Source)Vinod K. Vogirala(Diamond Light Source)Julika Radecke(Diamond Light Source)L. Moynié(Rosalind Franklin Institute)Yuguang Zhao(Centre for Human Genetics)Javier Gilbert‐Jaramillo(University of Oxford)Michael L. Knight(University of Oxford)Julia A. Tree(Public Health England)Karen R. Buttigieg(Public Health England)Naomi S. Coombes(Public Health England)Michael J. Elmore(Public Health England)Miles W. Carroll(Public Health England)Loïc Carrique(Centre for Human Genetics)Pranav N. M. Shah(Centre for Human Genetics)William James(University of Oxford)Alain Townsend(Academy of Medical Sciences)David I. Stuart(Centre for Human Genetics)Raymond J. Owens(Centre for Human Genetics)James H. Naismith(Centre for Human Genetics)
SARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies ResearchViral gastroenteritis research and epidemiologyNeutralizationNeutralizing antibodyVirologyViral entryAntibodyTrimerCoronavirusChemistryEpitopeBinding site
MeSH terms
BetacoronavirusAngiotensin-Converting Enzyme 2COVID-19SARS-CoV-2Amino Acid SequenceAntibodies, ViralAntibody AffinityAntigen-Antibody ReactionsEpitopesBinding, CompetitiveHumansImmunoglobulin Fc FragmentsPeptidyl-Dipeptidase AModels, MolecularPneumonia, Viral
Funding
- Wellcome Trust
- Diamond Light Source
- Cancer Research UK
- University of Oxford
- Chinese Academy of Medical Sciences
- Directorate for Biological Sciences
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council
Citations
546
FWCI
11.99
field-weighted impact
References
77
Percentile
99%
vs. same field & year
Citations per year
Cited by
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