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The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis

The Journal of Infectious Diseases · 2014 · Vol. 211(1) · pp. 80–90
John Mair-JenkinsMaría Saavedra-CamposJ. Kenneth BailliePaul ClearyFu-Meng KhawWei Shen LimSophia MakkiKevin RooneyConvalescent Plasma Study GroupJonathan S. Nguyen‐Van‐TamCharles Beck

Abstract

Convalescent plasma may reduce mortality and appears safe. This therapy should be studied within the context of a well-designed clinical trial or other formal evaluation, including for treatment of Middle East respiratory syndrome coronavirus CoV infection.

Respiratory viral infections researchPediatric health and respiratory diseasesSARS-CoV-2 and COVID-19 ResearchConvalescent plasmaMedicineImmunologyAntibodyMeta-analysisEtiologyRespiratory systemVirologyCoronavirus disease 2019 (COVID-19)Internal medicine

MeSH terms

HumansImmunoglobulinsInfluenza, HumanPlasmaProspective StudiesRespiratory Tract InfectionsRiskSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirus

Funding

  • World Health Organization
  • Public Health Agency
  • Public Health England
  • Universitetet i Bergen
  • Haukeland Universitetssjukehus
  • Folkhälsomyndigheten
Citations
1,038
FWCI
19.52
field-weighted impact
References
53
Percentile
100%
vs. same field & year
Citations per year
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