article Open AccessTop 1% cited
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Science Advances · 2020 · Vol. 6(28)
Arun C. Habermann(Vanderbilt University Medical Center)Austin J. Gutierrez(Translational Genomics Research Institute)Linh T. Bui(Translational Genomics Research Institute)Stephanie L. Yahn(Translational Genomics Research Institute)Nichelle I. Winters(Vanderbilt University Medical Center)Carla L. Calvi(Vanderbilt University Medical Center)Lance Peter(Translational Genomics Research Institute)Mei-I Chung(Translational Genomics Research Institute)Chase J. Taylor(Vanderbilt University Medical Center)Christopher S. Jetter(Vanderbilt University Medical Center)Latha Raju(Vanderbilt University Medical Center)Jamie Roberson(Vanderbilt University Medical Center)Guixiao Ding(Vanderbilt University Medical Center)Lori Wood(Tucson Orthopaedic Institute)Jennifer M. S. Sucre(Vanderbilt University Medical Center)Bradley W. Richmond(Vanderbilt University Medical Center)Ana Serezani(Vanderbilt University Medical Center)Wyatt J. McDonnell(Vanderbilt University Medical Center)S. Mallal(Murdoch University)Matthew J. Bacchetta(Vanderbilt University Medical Center)James E. Loyd(Vanderbilt University Medical Center)Ciara M. Shaver(Vanderbilt University Medical Center)Lorraine B. Ware(Vanderbilt University Medical Center)Ross M. Bremner(Tucson Orthopaedic Institute)Rajat Walia(Tucson Orthopaedic Institute)Timothy S. Blackwell(Vanderbilt University)Nicholas E. Banovich✉(Translational Genomics Research Institute)Jonathan A. Kropski✉(Vanderbilt University)
Abstract
Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.
Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisNeonatal Respiratory Health ResearchExtracellular vesicles in diseaseMesenchymal stem cellRNABiologyCellPulmonary fibrosisLungFibrosisCell biologyPathologyGene
Funding
- Doris Duke Charitable Foundation
- National Heart, Lung, and Blood Institute
Citations
1,054
FWCI
72.40
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References
70
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100%
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Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis
American Journal of Respiratory and Critical Care Medicine · 2018 · 1,246 citations
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