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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Cell · 2020 · Vol. 182(4) · pp. 812–827.e19
Bette KorberWill FischerS. GnanakaranHyejin YoonJames TheilerWerner AbfaltererNicolas HengartnerElena GiorgiTanmoy BhattacharyaBrian FoleyKathryn M. HastieMatthew ParkerDavid G. PartridgeCariad EvansTimothy M. FreemanThushan I. de SilvaAdrienne AngyalRebecca L. BrownLaura CarrileroLuke R. GreenDanielle C. GrovesKatie JohnsonAlexander J. KeeleyBenjamin B. LindseyPaul J. ParsonsMohammad RazaSarah L. Rowland-JonesDarren SmithRachel TuckerDennis WangMatthew D. WylesCharlene McDanalLautaro G. PerezHaili TangAlex Moon-WalkerSean P. J. WhelanCelia C. LaBrancheErica O. SaphireDavid C. Montefiori
SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingCOVID-19 epidemiological studiesBiologyInfectivitySpike (software development)VirusVirologyTiterCoronavirus disease 2019 (COVID-19)PandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Viral load

MeSH terms

BetacoronavirusCOVID-19SARS-CoV-2HospitalizationHumansPhylogenyPneumonia, ViralRespiratory SystemSeverity of Illness IndexGenetic VariationCoronavirus InfectionsViral LoadGeographic Information SystemsGenetic FitnessPandemics

Funding

  • U.S. Department of Health and Human Services
  • Bill and Melinda Gates Foundation
  • Wellcome Trust
  • UK Research and Innovation
  • Vaccine Research Center
  • National Institute for Health and Care Research
  • The Wellcome Trust DBT India Alliance
  • National Institutes of Health
  • University of California, San Diego
  • Medical Research Council
  • NIHR Sheffield Biomedical Research Centre
  • National Institute of Allergy and Infectious Diseases
  • Laboratory Directed Research and Development
  • Los Alamos National Laboratory
Citations
4,457
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