articleTop 1% cited

α-Synuclein aggregation nucleates through liquid–liquid phase separation

Nature Chemistry · 2020 · Vol. 12(8) · pp. 705–716

Soumik Ray✉(Indian Institute of Technology Bombay)Nitu Singh(Indian Institute of Technology Bombay)Rakesh Kumar(Indian Institute of Technology Bombay)Komal Patel(Indian Institute of Technology Bombay)Satyaprakash Pandey(Indian Institute of Technology Bombay)Debalina Datta(Indian Institute of Technology Bombay)Jaladhar Mahato(Indian Institute of Technology Bombay)Rajlaxmi Panigrahi(Indian Institute of Technology Bombay)Ambuja Navalkar(Indian Institute of Technology Bombay)Surabhi Mehra(Indian Institute of Technology Bombay)Laxmikant Gadhe(Indian Institute of Technology Bombay)Debdeep Chatterjee(Indian Institute of Technology Bombay)Ajay Singh Sawner(Indian Institute of Technology Bombay)S.K. Maiti(Indian Institute of Technology Bombay)Sandhya Bhatia(Tata Institute of Fundamental Research)Juan Gerez(ETH Zurich)Arindam Chowdhury(Indian Institute of Technology Bombay)Ashutosh Kumar(Indian Institute of Technology Bombay)Ranjith Padinhateeri(Indian Institute of Technology Bombay)Roland Riek(ETH Zurich)G. Krishnamoorthy(Anna University, Chennai)Samir K. Maji(Indian Institute of Technology Bombay)

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Parkinson's Disease Mechanisms and Treatments Amyotrophic Lateral Sclerosis Research Alzheimer's disease research and treatmentsChemistryLiquid liquidAggresomeNucleationAmyloid (mycology)BiophysicsFibrilProtein aggregationPathogenesisChromatography

MeSH terms

HeLa CellsHumansHydrogen-Ion ConcentrationParkinson DiseasePolyethylene GlycolsRecombinant ProteinsMutagenesis, Site-DirectedMicroscopy, ConfocalPhase Transitionalpha-SynucleinProtein Aggregates

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858

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38.44

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References

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins