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Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

Gastroenterology · 2020 · Vol. 159(3) · pp. 944–955.e8

Tao Zuo(Chinese University of Hong Kong)Fen Zhang(Chinese University of Hong Kong)Grace Lui(Chinese University of Hong Kong)Yun Kit Yeoh(Chinese University of Hong Kong)Amy Y. L. Li(Chinese University of Hong Kong)Hui Zhan(Chinese University of Hong Kong)Yating Wan(Chinese University of Hong Kong)Arthur Chung(Chinese University of Hong Kong)Chun Pan Cheung(Chinese University of Hong Kong)Nan Chen(Chinese University of Hong Kong)Christopher K.C. Lai(Chinese University of Hong Kong)Zigui Chen(Chinese University of Hong Kong)Eugene Y. K. Tso(United Christian Hospital)Kitty S. C. Fung(United Christian Hospital)Veronica Chan(United Christian Hospital)Lowell Ling(Chinese University of Hong Kong)Gavin M. Joynt(Chinese University of Hong Kong)David S.C. Hui(Chinese University of Hong Kong)Francis K.L. Chan(Chinese University of Hong Kong)Paul K.S. Chan✉(Chinese University of Hong Kong)Siew C. Ng✉(Chinese University of Hong Kong)

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Abstract

In a pilot study of 15 patients with COVID-19, we found persistent alterations in the fecal microbiome during the time of hospitalization, compared with controls. Fecal microbiota alterations were associated with fecal levels of SARS-CoV-2 and COVID-19 severity. Strategies to alter the intestinal microbiota might reduce disease severity.

Gut microbiota and health Diet and metabolism studies Clostridium difficile and Clostridium perfringens researchCoronavirus disease 2019 (COVID-19)Gut flora2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MedicineVirologyInternal medicineImmunologyOutbreakDisease

MeSH terms

Gastrointestinal MicrobiomeBetacoronavirusCOVID-19SARS-CoV-2AdultAgedFecesFemaleHong KongHospitalizationHumansMaleMiddle AgedPilot ProjectsPneumonia, Viral

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