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Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

Gut · 2021 · Vol. 70(4) · pp. 698–706

Yun Kit Yeoh(Chinese University of Hong Kong)Tao Zuo(Chinese University of Hong Kong)Grace Lui(Chinese University of Hong Kong)Fen Zhang(Chinese University of Hong Kong)Qin Liu(Chinese University of Hong Kong)Amy Y. L. Li(Chinese University of Hong Kong)Arthur Chung(Chinese University of Hong Kong)Chun Pan Cheung(Chinese University of Hong Kong)Eugene Y. K. Tso(United Christian Hospital)Kitty SC Fung(United Christian Hospital)Veronica Chan(United Christian Hospital)Lowell Ling(Chinese University of Hong Kong)Gavin M. Joynt(Chinese University of Hong Kong)David Hui(Chinese University of Hong Kong)Kai Ming Chow(Chinese University of Hong Kong)Susanna S. Ng✉(Chinese University of Hong Kong)Susanna S. Ng(Chinese University of Hong Kong)Timothy Chun-Man Li(Chinese University of Hong Kong)Rita W. Y. Ng(Chinese University of Hong Kong)Terry Cheuk‐Fung Yip(Chinese University of Hong Kong)Grace Lai–Hung Wong(Chinese University of Hong Kong)Francis K.L. Chan(Chinese University of Hong Kong)Chun Kwok Wong(Chinese University of Hong Kong)Paul K.S. Chan(Chinese University of Hong Kong)Siew C Ng✉(Chinese University of Hong Kong)Siew C Ng(Chinese University of Hong Kong)

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Abstract

Associations between gut microbiota composition, levels of cytokines and inflammatory markers in patients with COVID-19 suggest that the gut microbiome is involved in the magnitude of COVID-19 severity possibly via modulating host immune responses. Furthermore, the gut microbiota dysbiosis after disease resolution could contribute to persistent symptoms, highlighting a need to understand how gut microorganisms are involved in inflammation and COVID-19.

Gut microbiota and health COVID-19 Clinical Research Studies Clostridium difficile and Clostridium perfringens researchDysfunctional familyCoronavirus disease 2019 (COVID-19)Immune systemDiseaseImmunologyGut flora2019-20 coronavirus outbreakMedicineInternal medicinePathology

MeSH terms

Gastrointestinal MicrobiomeCOVID-19SARS-CoV-2AdultBacteriaC-Reactive ProteinDNA, BacterialFemaleHong KongHumansImmunityMaleSeverity of Illness IndexTransferasesCytokines