article Open AccessTop 1% cited
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
Molecular Cell · 2020 · Vol. 78(4) · pp. 779–784.e5
Markus Hoffmann✉(German Primate Center)Hannah Kleine‐Weber(German Primate Center)Stefan Pöhlmann✉(German Primate Center)
SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesVirus-based gene therapy researchFurinBiologyCleavage (geology)CoronavirusVirologyProteaseVirulenceCellVirusCell biology
MeSH terms
BetacoronavirusCOVID-19SARS-CoV-2AnimalsCell LineChlorocebus aethiopsHumansLungPneumonia, ViralSerine EndopeptidasesVero CellsCoronavirus InfectionsFurinVirus AttachmentPandemics
Funding
- Bundesministerium für Bildung und Forschung
Citations
2,057
FWCI
43.98
field-weighted impact
References
53
Percentile
100%
vs. same field & year
Citations per year
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References
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
Journal of Virology · 2011 · 1,201 citations
Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2
Journal of Virology · 2010 · 841 citations
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
Journal of Virology · 2010 · 757 citations
A novel coronavirus outbreak of global health concern
The Lancet · 2020 · 8,079 citations
A Novel Coronavirus from Patients with Pneumonia in China, 2019
New England Journal of Medicine · 2020 · 30,188 citations
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Nature · 2020 · 23,190 citations
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