article Open AccessTop 1% cited
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Cell · 2020 · Vol. 181(2) · pp. 281–292.e6
Alexandra C. Walls✉(University of Washington)Young‐Jun Park(University of Washington)M. Alejandra Tortorici(University of Washington)Abigail Wall(Fred Hutch Cancer Center)Andrew T. McGuire(University of Washington)David Veesler(University of Washington)
SARS-CoV-2 and COVID-19 ResearchViral Infections and Outbreaks ResearchAnimal Virus Infections StudiesEctodomainBiologyFurinGlycoproteinVirologyEpitopeAntigenicityPolyclonal antibodiesAntibodyViral entry
MeSH terms
BetacoronavirusAngiotensin-Converting Enzyme 2SARS-CoV-2Amino Acid SequenceAntigens, ViralCell LineHumansPeptidyl-Dipeptidase AModels, MolecularReceptors, VirusCryoelectron MicroscopySevere acute respiratory syndrome-related coronavirusVirus InternalizationAntibodies, NeutralizingSpike Glycoprotein, Coronavirus
Funding
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
Citations
9,028
FWCI
202.54
field-weighted impact
References
101
Percentile
100%
vs. same field & year
Citations per year
Cited by
Coronavirus Disease 2019–COVID-19
Clinical Microbiology Reviews · 2020 · 1,850 citations
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
Journal of General Virology · 2020 · 630 citations
The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control
Journal of Clinical Medicine · 2020 · 724 citations
COVID-19 pandemic, coronaviruses, and diabetes mellitus
American Journal of Physiology-Endocrinology and Metabolism · 2020 · 890 citations
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
Circulation Research · 2020 · 1,893 citations
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
Molecular Cell · 2020 · 2,057 citations
The trinity of COVID-19: immunity, inflammation and intervention
Nature reviews. Immunology · 2020 · 4,600 citations
Mechanisms of SARS-CoV-2 entry into cells
Nature Reviews Molecular Cell Biology · 2021 · 3,127 citations
References
Role of Hemagglutinin Cleavage for the Pathogenicity of Influenza Virus
Virology · 1999 · 665 citations
Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia
Emerging infectious diseases · 2013 · 722 citations
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
Journal of Virology · 2011 · 1,201 citations
The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex
Journal of Virology · 2003 · 1,568 citations
Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2
Journal of Virology · 2010 · 841 citations
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
Journal of Virology · 2010 · 757 citations
Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta
eLife · 2016 · 554 citations
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
Nature Methods · 2017 · 10,267 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.