review Open AccessTop 1% cited

Life, death, and autophagy in cancer: NF-κB turns up everywhere

Cell Death and Disease · 2020 · Vol. 11(3) · pp. 210–210

Daniela Verzella✉(University of L'Aquila)Alessandra Pescatore(Institute of Genetics and Biophysics)Daria Capece(Centre for Inflammation Research)Davide Vecchiotti(University of L'Aquila)Matilde Valeria Ursini(Institute of Genetics and Biophysics)Guido Franzoso(Imperial College London)Edoardo Alesse(University of L'Aquila)Francesca Zazzeroni(University of L'Aquila)

View via DOI Full-text PDF

Abstract

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.

Autophagy in Disease and Therapy NF-κB Signaling Pathways Cancer-related molecular mechanisms researchNecroptosisAutophagyProgrammed cell deathNF-κBRegulatorCell biologyTranscription factorBiologyCancer researchSignal transduction