Phytochemical screening and subacute toxicity evaluation of stem leaves of Monechma depauperatum (T. Anderson) on Wistar rats liver and kidney functions

Abstract

The objective main of this study is to perform phytochemical screening and to evaluate in vivo the subacute oral toxicity of the aqueous extract of Monechma depauperatum (T. Anderson). The screening is carried according to the method of (Houghton and Raman, 1998) and exploratory tests of subacute oral toxicity are carried in vivo on Wistar albinos rats in accordance with the OECD guidelines (423). The phytochemical analysis performed on the aqueous extract of Monechma depauperatum (T. Anderson) revealed the presence of tannins, anthocyanins, leucoanthocyans, anthraquinones, flavonoids, mucilages, saponosides and terpernes and sterols. The subacute oral toxicity tests of the aqueous extract of Monechma depauperatum (T. Anderson) showed no toxic effect on the biochemical parameters studied up to the 2000 mg/kg dose and became toxic at a dose of 2500 mg/kg. The lethal dose is therefore greater than 2000 mg/kg.