Phytochemical screening, acute and subacute toxicity of aqueous extract of Moringa oleifera (Moringaceae) Lam 1885 on rats wistar

Abstract

Due to the many therapeutic and nutritional properties of Moringa oleifera, an emphasis has been placed on its richness in secondary metabolites and its safety through an aqueous extract of its leaves. Specific reagents identified secondary metabolites with pharmaceutical effects. The acute and subacute toxicity test was conducted according to The Organization for Economic Co-operation and Development Guideline 423 and 407, respectively, on males and female rats, Wistar strain. Phytochemical screening revealed the presence of sterols and polysterols, polyphenols, flavonoids and saponosides. The lethal dose 50% of the extract is greater than 5000 mg / kg of body weight. The extract significantly reduced females to Alanine-aminotransferase at a dose of 300 mg / kg of body weight. The study showed the richness of secondary metabolites, the safety of the aqueous leaf extract of Moringa oleifera and its hepatoprotective effect.