review Open AccessTop 1% cited
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
The Lancet Neurology · 2019 · Vol. 18(12) · pp. 1091–1102
Mike A. Nalls✉(National Institutes of Health)Cornelis Blauwendraat(National Institutes of Health)Costanza L. Vallerga(The University of Queensland)Karl Heilbron(23andMe (United States))Sara Bandrés‐Ciga(National Institutes of Health)Diana ChangManuela Tan(Queen Mary University of London)Demis A. Kia(Queen Mary University of London)Alastair J. Noyce(The University of Queensland)Angli Xue(Van Andel Institute)José Brás(Van Andel Institute)Emily Young(University of Maryland, Baltimore)Rainer von Coelln(University of Maryland, Baltimore)Javier Simón-Sánchez(German Center for Neurodegenerative Diseases)Claudia Schulte(Hertie Institute for Clinical Brain Research)Manu Sharma(Montreal Neurological Institute and Hospital)Lynne Krohn(Oslo University Hospital)Lasse Pihlstrøm(Oslo University Hospital)Ari Siitonen(National Institutes of Health)Hirotaka Iwaki(National Institutes of Health)Hampton L. Leonard(National Institutes of Health)Faraz Faghri(National Institutes of Health)J Raphael Gibbs(National Institutes of Health)Dena Hernández(National Institutes of Health)Sonja W. Scholz(National Institute of Neurological Disorders and Stroke)Juan A. Botía(Université Toulouse III - Paul Sabatier)María Martínez(Centre National de la Recherche Scientifique)Jean‐Christophe Corvol(Centre National de la Recherche Scientifique)Suzanne Lesage(Centre National de la Recherche Scientifique)Joseph Jankovic(University of Maryland, Baltimore)Lisa M. Shulman(University of Maryland, Baltimore)Margaret Sutherland(National Institutes of Health)Pentti J. Tienari(University of Helsinki)Kari Majamaa(Oslo University Hospital)Mathias Toft(Oslo University Hospital)Ole A. Andreassen(Oslo University Hospital)Tushar Bangale(Centre National de la Recherche Scientifique)Alexis Brice(Centre National de la Recherche Scientifique)Jian Yang(Montreal Neurological Institute and Hospital)Ziv Gan‐Or(Montreal Neurological Institute and Hospital)Thomas Gasser(German Center for Neurodegenerative Diseases)Peter Heutink(Baylor College of Medicine)Joshua Shulman(Baylor College of Medicine)Nicholas Wood(Queen Mary University of London)David A. Hinds(23andMe (United States))John Hardy(National Hospital for Neurology and Neurosurgery)Huw R Morris(The University of Queensland)Jacob Gratten(The University of Queensland)Peter M. Visscher(The University of Queensland)Robert Graham(National Institutes of Health)Andrew B Singleton(National Institutes of Health)Astrid Adarmes‐GómezMiquel AguilarAkbota AitkulovaVadim AkhmetzhanovRoy N. AlcalayIgnacio ÁlvarezVictoria Álvarez(National Institutes of Health)Sara Bandrés‐Ciga(National Institutes of Health)Francisco Javier BarreroJesús Alberto Bergareche YarzaInmaculada Bernal‐BernalKimberley J. Billingsley(National Institutes of Health)Cornelis Blauwendraat(National Institutes of Health)Marta Blázquez EstradaMarta Bonilla‐Toribio(National Hospital for Neurology and Neurosurgery)Juan A. Botía(University College London)María Teresa Boungiorno(Van Andel Institute)José Brás(Centre National de la Recherche Scientifique)Alexis Brice(Centre National de la Recherche Scientifique)Kathrin BrockmannVivien J. BubbDolores Buiza‐RuedaAnna Maria Novella CàmaraFátima CarrilloMario Carrión‐ClaroDebora CerdanViorica ChelbanJordi ClarimónCarl E ClarkeYaroslau ComptaMark Cookson(Centre National de la Recherche Scientifique)Jean‐Christophe Corvol(Centre National de la Recherche Scientifique)David W. CraigFabrice DanjouMónica Díez-FairénOriol Dols‐IcardoJ. DuarteRaquel DuránFrancisco Escamilla‐SevillaValentina Escott‐PriceMario Ezquerra(National Institutes of Health)Faraz Faghri(University of Illinois Urbana-Champaign)Cici FelizManel FernándezRubén Fernández‐SantiagoSteven Finkbeiner(German Center for Neurodegenerative Diseases)Thomas Foltynie(Montreal Neurological Institute and Hospital)Ziv Gan‐Or(Montreal Neurological Institute and Hospital)Ciara GarcíaPedro Ruiz(German Center for Neurodegenerative Diseases)Thomas Gasser(National Institutes of Health)J Raphael Gibbs(National Institutes of Health)María José Gómez HerediaPilar Gómez‐GarreManuel Menéndez‐GonzálezIsabel González AramburuSebastian GuelfiRita Guerreiro(National Hospital for Neurology and Neurosurgery)John Hardy(National Hospital for Neurology and Neurosurgery)Sharon Hassin‐Baer(National Institutes of Health)Dena Hernández(National Institutes of Health)Peter Heutink(Hertie Institute for Clinical Brain Research)Janet Hoenicka(The University of Queensland)Peter HolmansHenry HouldenJon Infante(National Institutes of Health)Hirotaka Iwaki(National Institute on Aging)Silvia JesúsAdriano Jiménez‐EscrigGulnaz KaishybayevaRauan KaiyrzhanovAltynay Karimova(National Hospital for Neurology and Neurosurgery)Demis A. Kia(Queen Mary University of London)Kerri J. KinghornSulev Kõks(Montreal Neurological Institute and Hospital)Lynne Krohn(Montreal Neurological Institute and Hospital)Jaime KulisevskyMiguel A. Labrador‐Espinosa(National Institutes of Health)Hampton L. Leonard(Centre National de la Recherche Scientifique)Suzanne Lesage(Centre National de la Recherche Scientifique)Patrick A. LewisJosé Luis López-SendónRuth C. LoveringSteven LubbeCodrin LunguDaniel Macías(Oulu University Hospital)Kari Majamaa(Oulu University Hospital)Claudia Manzoni(National Hospital for Neurology and Neurosurgery)Juan Marín‐LahozJohan Marinus(Université Toulouse III - Paul Sabatier)Marı́a José Martı́(Université Toulouse III - Paul Sabatier)María Martínez(Université Toulouse III - Paul Sabatier)Irene Martínez‐TorresJuan Carlos Martínez‐CastrilloMarina MataNiccolò E. MencacciCarlota Méndez‐del‐BarrioBen MiddlehurstAdolfo Mínguez‐CastellanosPablo MirKin Y. Mok(National Hospital for Neurology and Neurosurgery)Huw R Morris(National Hospital for Neurology and Neurosurgery)Esteban Muñoz✉(National Institutes of Health)Mike A Nalls(Data Tecnica International (United States))Derek P. Narendra(Queen Mary University of London)Alastair J. Noyce(Queen Mary University of London)Oluwadamilola O. OjoNjideka OkubadejoAna Gorostidi PagolaPau PástorFrancisco Pérez ErrazquinMaría Teresa Periñán(Oslo University Hospital)Lasse PihlstrømHélène Plun‐Favreau(National Hospital for Neurology and Neurosurgery)John P. Quinn(Oslo University Hospital)Lea R’BiboXylena ReedElisabet Mondragón RezolaMie RizigPatrizia RizzuLaurie RobakA RodríguezGuy A. Rouleau(German Center for Neurodegenerative Diseases)Javier Ruiz‐MartínezClara RuzMina RytenDinara Sadykova(National Institutes of Health)Sonja W. Scholz(National Institute of Neurological Disorders and Stroke)Sebastian R. Schreglmann(German Center for Neurodegenerative Diseases)Claudia Schulte(Hertie Institute for Clinical Brain Research)Manu Sharma(University of Tübingen)Chingiz Shashkin(Baylor College of Medicine)Joshua Shulman(Université Toulouse III - Paul Sabatier)María Sierra(Oulu University Hospital)Ari Siitonen(Oulu University Hospital)Javier Simón-Sánchez(National Institutes of Health)Andrew B Singleton(National Institutes of Health)Esther Suárez-SanmartínPille TabaCésar Tabernero(National Hospital for Neurology and Neurosurgery)Manuela X Tan(Queen Mary University of London)Juan Pablo TartariCristina Tejera‐Parrado(Oslo University Hospital)Mathias Toft(Oslo University Hospital)Eduard TolosaDaniah TrabzuniFrancesc ValldeoriolaJacobus J. van HiltenKendall Van Keuren‐JensenLaura Vargas‐GonzálezLydia VelaFrancisco VivesNigel Williams(National Hospital for Neurology and Neurosurgery)Nicholas Wood(Queen Mary University of London)Nazira ZharkinbekovaZharkyn JarmukhanovElena ZholdybayevaAlexander ZimprichPauli Ylikotila(University of Maryland, Baltimore)Lisa M. Shulman(University of Maryland, Baltimore)Rainer von Coelln(University of Maryland, Baltimore)Stephen G. Reich(Baylor College of Medicine)Joseph M. SavittMichelle AgeeBabak AlipanahiAdam AutonRobert K. BellKatarzyna BrycSarah L. ElsonPierre Fontanillas(National Hospital for Neurology and Neurosurgery)Nicholas A. FurlotteKaren E. HuberBarry HicksEthan M. JewettYunxuan JiangAaron KleinmanKeng‐Han LinNadia K. LittermanJennifer C. McCreightMatthew H. McIntyreKimberly F. McManusJoanna L. MountainElizabeth S. NoblinCarrie A. M. NorthoverSteven J. PittsG. David PoznikJ. Fah SathirapongsasutiJanie F. SheltonSuyash ShringarpureChao TianJoyce Y. TungVladimir VacicXin WangCatherine H. WilsonTim AndersonSteven R. Bentley(National Hospital for Neurology and Neurosurgery)John C. Dalrymple‐AlfordJaved Fowdar(The University of Queensland)Jacob Gratten(The University of Queensland)Glenda M. HallidayAnjali K. Henders(The University of Queensland)Ian B. HickieIrfahan Kassam(Université Toulouse III - Paul Sabatier)Martin A. Kennedy(National Hospital for Neurology and Neurosurgery)John B. Kwok(German Center for Neurodegenerative Diseases)Simon J.G. LewisGeorge D. MellickGrant W. Montgomery(National Hospital for Neurology and Neurosurgery)John F. PearsonToni L. PitcherJulia Sidorenko(The University of Queensland)Peter A. Silburn(The University of Queensland)Costanza L. Vallerga(The University of Queensland)Peter M. Visscher(The University of Queensland)Leanne WallaceNaomi R. Wray(The University of Queensland)Angli Xue(The University of Queensland)Jian Yang(The University of Queensland)Futao Zhang
Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismRNA regulation and diseaseGenome-wide association studyDiseaseLRRK2Genetic associationSingle-nucleotide polymorphismMendelian randomizationGeneticsBiologyMeta-analysisMendelian inheritance
MeSH terms
HumansParkinson DiseaseRisk FactorsGenetic Predisposition to DiseaseDatabases, GeneticGenome-Wide Association StudyGenetic Loci
Funding
- Medical Research Council
Citations
2,465
FWCI
154.25
field-weighted impact
References
47
Percentile
100%
vs. same field & year
Citations per year
Cited by
Challenges in the diagnosis of Parkinson's disease
The Lancet Neurology · 2021 · 1,624 citations
Parkinson’s disease: etiopathogenesis and treatment
Journal of Neurology Neurosurgery & Psychiatry · 2020 · 1,119 citations
References
Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
Neurology · 2006 · 2,448 citations
Optimal Unified Approach for Rare-Variant Association Testing with Application to Small-Sample Case-Control Whole-Exome Sequencing Studies
The American Journal of Human Genetics · 2012 · 1,126 citations
GCTA: A Tool for Genome-wide Complex Trait Analysis
The American Journal of Human Genetics · 2010 · 9,109 citations
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
Proceedings of the National Academy of Sciences · 2005 · 55,472 citations
METAL: fast and efficient meta-analysis of genomewide association scans
Bioinformatics · 2010 · 5,672 citations
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Nature Genetics · 2015 · 6,093 citations
An atlas of genetic correlations across human diseases and traits
Nature Genetics · 2015 · 4,591 citations
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Nature Genetics · 2016 · 3,315 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.