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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

Cancer Cell · 2017 · Vol. 32(1) · pp. 42–56.e6

Qianghu Wang(The University of Texas MD Anderson Cancer Center)Baoli Hu(The University of Texas MD Anderson Cancer Center)Xin Hu(The University of Texas MD Anderson Cancer Center)Hoon Kim(Jackson Laboratory)Massimo Squatrito(Spanish National Cancer Research Centre)Lisa Scarpace(Henry Ford Hospital)Ana C. deCarvalho(Henry Ford Hospital)Sali Lyu(Nanjing Medical University)Pengping Li(Nanjing Medical University)Yan Li(Nanjing Medical University)Floris P Barthel(The University of Texas MD Anderson Cancer Center)Hee Jin Cho(Sungkyunkwan University)Yu-Hsi Lin(The University of Texas MD Anderson Cancer Center)Nikunj Satani(The University of Texas MD Anderson Cancer Center)Emmanuel Martínez-Ledesma(The University of Texas MD Anderson Cancer Center)Siyuan Zheng(The University of Texas MD Anderson Cancer Center)Edward F. Chang(The University of Texas MD Anderson Cancer Center)Charles-Etienne Gabriel Sauvé(The University of Texas MD Anderson Cancer Center)Adriana Olar(Medical University of South Carolina)Zheng D. Lan(The University of Texas MD Anderson Cancer Center)Gaetano Finocchiaro(Fondazione IRCCS Istituto Neurologico Carlo Besta)Joanna J. Phillips(University of California, San Francisco)Mitchel S. Berger(University of California, San Francisco)Konrad Gabrusiewicz(The University of Texas MD Anderson Cancer Center)Guocan Wang(The University of Texas MD Anderson Cancer Center)Eskil Eskilsson(The University of Texas MD Anderson Cancer Center)Jian Hu(The University of Texas MD Anderson Cancer Center)Tom Mikkelsen(Nanjing Medical University)Ronald A. DePinho(The University of Texas MD Anderson Cancer Center)Florian L. Müller(The University of Texas MD Anderson Cancer Center)Amy B. Heimberger(The University of Texas MD Anderson Cancer Center)Erik P. Sulman✉(The University of Texas MD Anderson Cancer Center)Do‐Hyun Nam✉(Sungkyunkwan University)Roel G.W. Verhaak✉(Jackson Laboratory)

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Glioma Diagnosis and Treatment Immune cells in cancer Neuroinflammation and Neurodegeneration MechanismsGliomaBiologyMicrogliaTumor microenvironmentTranscriptomeCancer researchCD8Gene expressionSomatic hypermutationImmunology

MeSH terms

GlioblastomaHumansPhenotypeRecurrenceT-LymphocytesGene Expression Regulation, NeoplasticSurvival AnalysisGene Expression ProfilingTumor Microenvironment