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Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

Cancer Cell · 2014 · Vol. 25(6) · pp. 846–859

Carola H. Ries✉(Roche Pharma AG (Germany))Michael A. Cannarile(Roche Pharma AG (Germany))Sabine Hoves(Roche Pharma AG (Germany))Jörg Benz(Roche (Switzerland))Katharina Wartha(Roche Pharma AG (Germany))Valeria Runza(Roche Pharma AG (Germany))Flora Rey-Giraud(Roche Pharma AG (Germany))Leon P. Pradel(Roche Pharma AG (Germany))Friedrich Feuerhake(Medizinische Hochschule Hannover)Irina Klaman(Roche Pharma AG (Germany))Tobin Jones(Roche Pharma AG (Germany))Ute Jucknischke(Roche Pharma AG (Germany))Stefan Scheiblich(Roche Pharma AG (Germany))Klaus Kaluza(Roche Pharma AG (Germany))Ingo H. Gorr(Roche Pharma AG (Germany))Antje‐Christine Walz(Roche (Switzerland))K. Abiraj(Roche (Switzerland))Philippe A. Cassier(Centre Léon Bérard)Antonio Sica(Humanitas University)Carlos Gomez-Roca(Institut Claudius Regaud)Karin E. de Visser(The Netherlands Cancer Institute)Antoîne Italiano(Institut Bergonié)Christophe Le Tourneau(Institut Curie)Jean‐Pierre Delord(Institut Claudius Regaud)Hyam I. Levitsky(Roche (Switzerland))Jean‐Yves Blay(Centre Léon Bérard)Dominik Rüttinger(Roche Pharma AG (Germany))

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Immune cells in cancer Immunotherapy and Immune Responses Phagocytosis and Immune RegulationAntibodyCancer researchCancer therapyCancerAntibody therapyMedicineImmunologyCancer cellBiologyMonoclonal antibody

MeSH terms

AnimalsAntibodies, MonoclonalCell DifferentiationColonic NeoplasmsFemaleHumansMacaca fascicularisMacrophagesMaleMice, Inbred C57BLModels, MolecularCohort StudiesReceptor, Macrophage Colony-Stimulating FactorClinical Trials, Phase I as TopicCell Line, Tumor