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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Nature Genetics · 2019 · Vol. 51(2) · pp. 237–244

Mengzhen Liu✉(University of Minnesota)HUNT All-In Psychiatry(Pennsylvania State University)Yu Jiang(Pennsylvania State University)Robbee Wedow(Pennsylvania State University)Yue Li(Broad Institute)David M. Brazel(Pennsylvania State University)Fang Chen(University of Minnesota)Gargi Datta(University of Minnesota)José Dávila-Velderrain(Broad Institute)Daniel McGuire(Pennsylvania State University)Chao Tian(23andMe (United States))Xiaowei Zhan(Kaiser Permanente)Hélène Choquet(Kaiser Permanente)Anna R. Docherty(Virginia Commonwealth University)Jessica D. Faul(University of Michigan)Johanna R. Foerster(University of Michigan)Lars G. Fritsche(Norwegian University of Science and Technology)Maiken E. Gabrielsen(Norwegian University of Science and Technology)Scott D. Gordon(QIMR Berghofer Medical Research Institute)Jeffrey Haessler(Fred Hutch Cancer Center)Jouke‐Jan Hottenga(Harvard University)Hongyan Huang(University of Minnesota)Seon-Kyeong Jang(University of Minnesota)Philip R. Jansen(Pennsylvania State University)Yueh Ling(Pennsylvania State University)Reedik Mägi(RIKEN Center for Integrative Medical Sciences)Nana Matoba(RIKEN Center for Integrative Medical Sciences)George McMahon(Institute of Genetic and Biomedical Research)Antonella Mulas(Institute of Genetic and Biomedical Research)Valeria Orrù(University of Helsinki)Teemu Palviainen(University of Helsinki)Anita Pandit(deCODE Genetics (Iceland))Gunnar W. Reginsson(deCODE Genetics (Iceland))Anne Heidi Skogholt(Norwegian University of Science and Technology)Jennifer A. Smith(University of Michigan)Amy E. Taylor(Harvard University)Constance Turman(Harvard University)Gonneke Willemsen(University of Minnesota)Hannah Young(University of Minnesota)Kendra A. Young(University of Michigan)Gregory J. M. Zajac(University of Michigan)Wei Zhao(University of Michigan)Wei Zhou(deCODE Genetics (Iceland))Gyða Björnsdóttir(deCODE Genetics (Iceland))Jason D. Boardman(University of Colorado Boulder)Michael Boehnke(University of Michigan)Dorret I. Boomsma(Fred Hutch Cancer Center)Chu Chen(Fred Hutch Cancer Center)Francesco Cucca(Avera Health)Gareth E. Davies(Brown University)Charles B. Eaton(University of Colorado Boulder)Marissa A. Ehringer(Broad Institute)Tōnu Esko(Broad Institute)Edoardo Fiorillo(Virginia Commonwealth University)Nathan A. Gillespie(deCODE Genetics (Iceland))Daníel F. Guðbjartsson(deCODE Genetics (Iceland))Toomas Haller(University of North Carolina at Chapel Hill)Kathleen Mullan Harris(University of North Carolina at Chapel Hill)Andrew C. Heath(University of Colorado Boulder)John K. Hewitt(The University of Sydney)Ian B. Hickie(The University of Sydney)John E. Hokanson(University of Colorado Boulder)Christian J. Hopfer(Harvard University)David J. Hunter(University of Minnesota)William G. Iacono(University of Minnesota)Eric O. Johnson(RTI International)Yoichiro Kamatani(University of Michigan)Sharon L. R. Kardia(University of Colorado Boulder)Matthew C. Keller(Broad Institute)Manolis Kellis(Broad Institute)Charles Kooperberg(Harvard University)Peter Kraft(Harvard University)Kenneth Krauter(University of Eastern Finland)Markku Laakso(University of Eastern Finland)Penelope A. Lind(University of Helsinki)Anu Loukola(University of Helsinki)Sharon M. Lutz(Washington University in St. Louis)Pamela A. F. Madden(Washington University in St. Louis)Nicholas G. Martin(University of Minnesota)Matt McGue(University of Minnesota)Matthew B. McQueen(University of Colorado Boulder)Sarah E. Medland(QIMR Berghofer Medical Research Institute)Andres Metspalu(University of North Carolina at Chapel Hill)Karen L. Mohlke(University of North Carolina at Chapel Hill)Jonas B. Nielsen(Michigan Medicine)Yukinori Okada(Fred Hutch Cancer Center)Ulrike Peters(University of Washington)Tinca J. C. Polderman(Vrije Universiteit Amsterdam)Daniëlle Posthuma(University of Washington)Alexander P. Reiner(University of Washington)John P. Rice(Harvard University)Eric B. Rimm(Harvard University)Richard J. Rose(Indiana University Bloomington)Valgerður Rúnarsdóttir(University of Colorado Boulder)Michael C. Stallings(University of Eastern Finland)Alena Stančáková(deCODE Genetics (Iceland))Hreinn Stefánsson(deCODE Genetics (Iceland))Khanh K. Thai(Kaiser Permanente)Hilary A. Tindle(Vanderbilt University)Þórarinn Tyrfingsson(University of California San Diego)Tamara L. Wall(University of Michigan)David R. Weir(Kaiser Permanente)Constance Weisner(Kaiser Permanente)John B. Whitfield(Oslo University Hospital)Bendik S. Winsvold(Oslo University Hospital)Jie Yin(Kaiser Permanente)Luisa Zuccolo(Washington University in St. Louis)Laura J. Bierut(Washington University in St. Louis)Kristian Hveem(University of Minnesota)James J. Lee(University of Minnesota)Marcus R. Munafò(Washington University in St. Louis)Nancy L. Saccone(Washington University in St. Louis)Cristen J. Willer(Northwestern University)Marilyn C. Cornelis(Northwestern University)Sean P. David(23andMe (United States))David A. Hinds(Kaiser Permanente)Eric Jorgenson(University of Helsinki)Jaakko Kaprio(University of Helsinki)Jerry A. Stitzel(deCODE Genetics (Iceland))Kāri Stefánsson(deCODE Genetics (Iceland))Thorgeir E. Thorgeirsson(deCODE Genetics (Iceland))Gonçalo R. Abecasis(Pennsylvania State University)Dajiang J. Liu(University of Minnesota)Scott Vrieze(University of Minnesota)

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Alcohol Consumption and Health Effects Genetic Associations and Epidemiology Substance Abuse Treatment and OutcomesBiologyGeneticsGenetic associationGenome-wide association studyAddictionAlcohol dependenceAlcoholGeneBioinformaticsGenotype

MeSH terms

Alcohol DrinkingFemaleHumansMaleMiddle AgedPhenotypeRiskSmokingNicotianaTobacco ProductsTobacco Use DisorderGenetic VariationGenome-Wide Association Study