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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

Immunity · 2019 · Vol. 50(1) · pp. 195–211.e10
Imran SiddiquiKarin SchaeubleVijaykumar ChennupatiSilvia A. Fuertes MarracoSandra P. Calderon-CopeteDaniela Pais FerreiraSantiago J. CarmonaLéonardo ScarpellinoDavid GfellerSylvain PradervandSanjiv A. LutherDaniel E. SpeiserWerner Held
Cancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy researchBlockadeCancer researchImmune checkpointBiologyImmunotherapyCD8Cytotoxic T cellMelanomaStem cellImmunology

MeSH terms

Hepatitis A Virus Cellular Receptor 2AnimalsAntibodies, MonoclonalCell DifferentiationHumansImmunotherapyMelanomaMelanoma, ExperimentalMice, Inbred C57BLStem CellsT-Lymphocyte SubsetsLymphocytes, Tumor-InfiltratingCD8-Positive T-LymphocytesCell ProliferationMice

Funding

  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Krebsliga Schweiz
  • National Science Foundation of Sri Lanka
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