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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Nature Genetics · 2019 · Vol. 51(3) · pp. 404–413

Iris E. Jansen(Amsterdam Neuroscience)Jeanne E. Savage(Amsterdam Neuroscience)Kyoko Watanabe(Amsterdam Neuroscience)Julien Bryois(Karolinska Institutet)Dylan M. Williams(Karolinska Institutet)Stacy Steinberg(deCODE Genetics (Iceland))Julia Sealock(Vanderbilt University)Ida Karlsson(Karolinska Institutet)Sara Hägg(Karolinska Institutet)Lavinia Athanasiu(Oslo University Hospital)Nicola Voyle(King's College London)Petroula Proitsi(King's College London)Aree Witoelar(University of Oslo)Sven Stringer(Amsterdam Neuroscience)Dag Aarsland(King's College London)Ina S. Almdahl(Oslo University Hospital)Fred Andersen(UiT The Arctic University of Norway)Sverre Bergh(Innlandet Hospital Trust)Francesco Bettella(University of Oslo)Sigurbjörn Björnsson(Reykjavík University)Anne Brækhus(Oslo University Hospital)Geir Bråthen(Norwegian University of Science and Technology)Christiaan de Leeuw(Amsterdam Neuroscience)Rahul S. Desikan(University of California, San Francisco)Srdjan Djurovic(Oslo University Hospital)Logan Dumitrescu(Vanderbilt University Medical Center)Tormod Fladby(University of Oslo)Timothy J. Hohman(Vanderbilt University Medical Center)Pálmi V. Jónsson(Reykjavík University)Steven J. Kiddle(University of Cambridge)Arvid Rongve(Fonna Hospital Trust)Ingvild Saltvedt(Norwegian University of Science and Technology)Sigrid Botne Sando(Norwegian University of Science and Technology)Geir Selbæk(University of Oslo)Maryam Shoai(University College London)Nathan Skene(Karolinska Institutet)Jón Snædal(Reykjavík University)Eystein Stordal(Norwegian University of Science and Technology)Ingun Ulstein(Oslo University Hospital)Yunpeng Wang(University of Oslo)Linda R. White(Norwegian University of Science and Technology)John Hardy(University College London)Jens Hjerling‐Leffler(Karolinska Institutet)Patrick F. Sullivan(University of North Carolina at Chapel Hill)Wiesje M. van der Flier(Amsterdam Neuroscience)Richard Dobson(University of London)Lea K. Davis(Vanderbilt University Medical Center)Hreinn Stefánsson(deCODE Genetics (Iceland))Kāri Stefánsson(deCODE Genetics (Iceland))Nancy L. Pedersen(Karolinska Institutet)Stephan Ripke(Broad Institute)Ole A. Andreassen(University of Oslo)Daniëlle Posthuma✉(Amsterdam Neuroscience)

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Genetic Associations and Epidemiology Alzheimer's disease research and treatments Bioinformatics and Genomic NetworksBiologyMendelian randomizationGenome-wide association studyDiseaseGeneticsAlzheimer's diseaseGenetic associationTREM2GeneGenome

MeSH terms

AdultAlzheimer DiseaseFemaleHumansMaleMiddle AgedRiskCase-Control StudiesGenetic Predisposition to DiseasePolymorphism, Single NucleotideQuantitative Trait LociGenome-Wide Association StudyYoung Adult

Funding

Alzheimer's Association
Case Western Reserve University
Wellcome Trust
EU Joint Programme – Neurodegenerative Disease Research
European Federation of Pharmaceutical Industries and Associations
Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease
Université de Lille
National Institute for Health and Care Research
European Commission
Institut National de la Santé et de la Recherche Médicale
Vrije Universiteit Amsterdam
Bundesministerium für Bildung und Forschung
Austrian Science Fund
Erasmus Medisch Centrum
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
University of Toronto
Oesterreichische Nationalbank
Österreichische Forschungsförderungsgesellschaft
Norges Forskningsråd
Karl-Franzens-Universität Graz
Medizinische Universität Graz
Hjartavernd
Nasjonalforeningen for Folkehelsen
Centre hospitalier régional universitaire de Lille
National Institutes of Health
Medical Research Council
National Institute on Aging
National Heart, Lung, and Blood Institute
National Institute on Deafness and Other Communication Disorders
National Institute of Neurological Disorders and Stroke