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Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

Neuron · 2014 · Vol. 82(2) · pp. 380–397
Monica R. P. ElmoreAllison R. NajafiMaya A. KoikeNabil N. DagherElizabeth E. SpangenbergRachel RiceMasashi KitazawaBernice MatusowHoa NguyenBrian L. WestKim N. Green
Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerImmune Response and InflammationMicrogliaNeuroscienceProgenitor cellReceptorBiologyCell biologyImmunologyStem cellGeneticsInflammation

MeSH terms

AnimalsAnimals, NewbornBrainEnzyme InhibitorsGene Expression RegulationLipopolysaccharidesMaleMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsTime FactorsSignal TransductionMacrophage Colony-Stimulating FactorReceptor, Macrophage Colony-Stimulating FactorCell Death

Funding

  • American Federation for Aging Research
  • National Institutes of Health
  • University of California, Irvine
  • National Institute of Neurological Disorders and Stroke
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