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Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression

International Journal of Epidemiology · 2018 · Vol. 47(4) · pp. 1264–1278
Jack BowdenWes SpillerFabiola Del Greco MNuala A. SheehanJohn R. ThompsonCosetta MinelliGeorge Davey Smith

Abstract

The Radial plot should be considered in place of the scatter plot for visualizing, analysing and interpreting data from a two-sample summary data MR study. Software is provided to help facilitate its use.

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and AnimalsMendelian randomizationPlot (graphics)OutlierRegressionStatisticsScatter plotSample size determinationComputer scienceData miningMathematics

MeSH terms

Data VisualizationHumansGenetic VariationGenetic Predisposition to DiseasePolymorphism, Single NucleotideMendelian Randomization AnalysisGenetic Pleiotropy

Funding

  • University of Bristol
  • Medical Research Council
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