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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Immunity · 2017 · Vol. 47(3) · pp. 566–581.e9

Susanne Krasemann(Harvard University)Charlotte Madore(Harvard University)Ron Cialic(Harvard University)Caroline Baufeld(Harvard University)Narghes Calcagno(Brigham and Women's Hospital)Rachid El Fatimy(Harvard University)Lien Beckers(Brigham and Women's Hospital)Elaine O’Loughlin(Harvard University)Yang Xu(University of Massachusetts Chan Medical School)Zain Fanek(Brigham and Women's Hospital)David Greco(Brigham and Women's Hospital)Scott Smith(Brigham and Women's Hospital)George Tweet(Brigham and Women's Hospital)Zachary Humulock(Brigham and Women's Hospital)Tobias Zrzavy(Medical University of Vienna)Patricia Conde-Sanroman(Icahn School of Medicine at Mount Sinai)Mar Gacias(Icahn School of Medicine at Mount Sinai)Zhiping Weng(University of Massachusetts Chan Medical School)Hao Chen(University of Massachusetts Chan Medical School)Emily Tjon(Brigham and Women's Hospital)Fargol Mazaheri(German Center for Neurodegenerative Diseases)Kristin Hartmann(Universität Hamburg)Asaf Madi(Harvard University)Jason D. Ulrich(Hope Center for Neurological Disorders)Markus Glatzel(University Medical Center Hamburg-Eppendorf)Anna Worthmann(University Medical Center Hamburg-Eppendorf)Jöerg Heeren(Universität Hamburg)Bogdan Budnik(Harvard University)Cynthia A. Lemere(Brigham and Women's Hospital)Tsuneya Ikezu(Boston University)Frank L. Heppner(Charité - Universitätsmedizin Berlin)Vladimir Litvak(University of Massachusetts Chan Medical School)David M. Holtzman(Hope Center for Neurological Disorders)Hans Lassmann(Medical University of Vienna)Howard L. Weiner(Harvard University)Jordi Ochando(Icahn School of Medicine at Mount Sinai)Christian Haass(Ludwig-Maximilians-Universität München)Oleg Butovsky✉(Harvard University)

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Neuroinflammation and Neurodegeneration Mechanisms Inflammation biomarkers and pathways Neurological Disease Mechanisms and TreatmentsTREM2MicrogliaNeurodegenerationApolipoprotein EBiologyNeuroscienceNeuroinflammationAmyotrophic lateral sclerosisPhenotypeImmunology

MeSH terms

Superoxide Dismutase-1Alzheimer DiseaseAnimalsApolipoproteins ECerebral CortexDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleGene Expression RegulationHumansImmune ToleranceMembrane GlycoproteinsMice, TransgenicMonocytesNeurons