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Identification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi B

Journal of Antimicrobial Chemotherapy · 2017 · Vol. 72(12) · pp. 3317–3324

Maria Borowiak(Federal Institute for Risk Assessment)Jennie Fischer(Federal Institute for Risk Assessment)Jens A. Hammerl(Federal Institute for Risk Assessment)René S. Hendriksen(Technical University of Denmark)István Szabó(Federal Institute for Risk Assessment)Burkhard Malorny✉(Federal Institute for Risk Assessment)

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Abstract

Our findings suggest that the transfer of colistin-resistance-mediating phosphoethanolamine transferase genes from bacterial chromosomes to mobile genetic elements has occurred in multiple independent events raising concern regarding their variety, prevalence and impact on public health.

Antibiotic Resistance in Bacteria Cassava research and cyanide Bacteriophages and microbial interactionsSalmonella entericaMicrobiologyColistinBiologySalmonellaMCR-1SerotypeEnterobacteriaceaeVirologyBacteria

MeSH terms

Anti-Bacterial AgentsCloning, MolecularColistinDNA Transposable ElementsEscherichia coliEthanolaminephosphotransferaseFermentationGermanyMicrobial Sensitivity TestsNucleic Acid HybridizationSalmonella paratyphi BTartratesTransformation, GeneticPolymerase Chain ReactionElectrophoresis, Gel, Pulsed-Field