articleTop 1% cited
Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity
Leukemia · 2017 · Vol. 32(2) · pp. 520–531
E Liu✉(The University of Texas MD Anderson Cancer Center)Yijiu Tong(The University of Texas MD Anderson Cancer Center)Gianpietro Dotti(University of North Carolina at Chapel Hill)Hila Shaim(The University of Texas MD Anderson Cancer Center)Barbara Savoldo(University of North Carolina at Chapel Hill)Malini Mukherjee(Baylor College of Medicine)Jordan S. Orange(Baylor College of Medicine)Xiaochun Wan(The University of Texas MD Anderson Cancer Center)Xinyan Lu(The University of Texas MD Anderson Cancer Center)Alex Reynolds(The University of Texas MD Anderson Cancer Center)Mihai Gagea(The University of Texas MD Anderson Cancer Center)Pinaki P. Banerjee(The University of Texas MD Anderson Cancer Center)Rong Cai(The University of Texas MD Anderson Cancer Center)Mustafa Bdaiwi(The University of Texas MD Anderson Cancer Center)Rafet Başar(The University of Texas MD Anderson Cancer Center)Muharrem Müftüoğlu(The University of Texas MD Anderson Cancer Center)Lin Li(The University of Texas MD Anderson Cancer Center)David Marín(The University of Texas MD Anderson Cancer Center)William G. Wierda(The University of Texas MD Anderson Cancer Center)Michael J. Keating(The University of Texas MD Anderson Cancer Center)Richard E. Champlin(The University of Texas MD Anderson Cancer Center)Elizabeth J. Shpall(The University of Texas MD Anderson Cancer Center)Katayoun Rezvani(The University of Texas MD Anderson Cancer Center)
Immune Cell Function and InteractionCAR-T cell therapy researchSuicide geneChimeric antigen receptorNK-92ImmunologyCytotoxic T cellCD19Interleukin 21Interleukin 12Cancer researchImmunotherapy
MeSH terms
Receptors, Chimeric AntigenAgedCytotoxicity, ImmunologicFemaleFetal BloodGraft vs Host DiseaseHumansKiller Cells, NaturalLeukemiaLymphomaMaleMiddle AgedT-LymphocytesImmunotherapy, AdoptiveAntigens, CD19
Citations
785
FWCI
22.36
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References
52
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100%
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References
Up on the tightrope: natural killer cell activation and inhibition
Nature Immunology · 2008 · 1,637 citations
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
Leukemia · 2010 · 554 citations
CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
Science Translational Medicine · 2013 · 2,062 citations
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
Blood · 2005 · 1,884 citations
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