articleTop 10% cited
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
Leukemia · 2010 · Vol. 24(6) · pp. 1160–1170
Valentina Hoyos✉(Baylor College of Medicine)Barbara Savoldo(Methodist Hospital)Concetta Quintarelli(Baylor College of Medicine)Aruna Mahendravada(Baylor College of Medicine)Ming Zhang(Houston Methodist)Juan F. Vera(Baylor College of Medicine)Helen E. Heslop(Texas Children's Hospital)Cliona M. Rooney(Methodist Hospital)Malcolm K. Brenner(Texas Children's Hospital)Gianpietro Dotti(Houston Methodist)
CAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell ImmunologySuicide geneChimeric antigen receptorCancer researchCD19Interleukin 3CD28AntigenLeukemiaT cellInterleukin 21
MeSH terms
AnimalsGenetic VectorsHumansLeukemiaLymphocyte ActivationLymphomaT-LymphocytesImmunophenotypingMice, SCIDAntigen PresentationCD28 AntigensAntigens, CD19Interleukin-15Xenograft Model Antitumor AssaysMice
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References
Immunosuppressive networks in the tumour environment and their therapeutic relevance
Nature reviews. Cancer · 2005 · 2,032 citations
Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
Leukemia · 2004 · 811 citations
Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
Blood · 2009 · 1,751 citations
A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer
Clinical Cancer Research · 2006 · 1,233 citations
PD-1 and Its Ligands in Tolerance and Immunity
Annual Review of Immunology · 2008 · 5,272 citations
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