CNS Depressant, Analgesic and Anti-inflammatory Activities of Methanolic Seed Extract of Calamus rotang Linn. Fruits in rat

Abstract

This study was aimed to investigate CNS depressant, analgesic and anti-inflammatory activities of methanolic seed extract of Calamus rotang (MCRS)in rats. Hole cross and open field tests for CNS depressant effect, acetic acid-induced writhing and formalin induced pain methods for analgesic and carrageenan-induced paw edema was performed to evaluate anti-inflammatory effect of the doses of 250 and 500 mg/kg b.w. respectively. In hole cross and open field tests, maximum suppression of locomotor activity were 81.42% and 86.61% with the higher dose (500 mg/kg) of extract, whereas for the standard drug diazepam (1 mg/kg) inhibition rate were 87.14% and 91.86% respectively. MCRS at the dose of 500 mg/kg exhibited maximum 51.27% inhibition against acetic acid-induced pain while indomethacin (10 mg/kg) displayed 58.86% inhibition. In formalin-induced test, 68.47% inhibition was produced by MCRS (500 mg/kg) and indomethacin produced 70.72% inhibition. In anti-inflammatory activity, the extract showed a significant (p