Investigation of analgesic and cytotoxic activities of ethanol extract of Commelina appendiculata

Abstract

The present study was aimed to evaluate the possible analgesic and cytotoxic activities of the ethanol extract of Commelina appendiculata (EECA) (Family: Commelinaceae). Acetic acid-induced writhing, hot plate and tail immersion methods in swiss albino mice at the doses of 100 and 200 mg/kg body weight, p.o were used for the determination of analgesic activity. Brine shrimp lethality bioassay was carried out for assessing the cytotoxicity. Phytochemical screening of ethanol extract of C. appendiculata demonstrated the presence of carbohydrates, flavonoids, tannins, glycosides and alkaloids. In analgesic activity study, both doses of the extract produced a significant (p < 0.05 and p