review Open AccessTop 1% cited
mTORC1 signaling and the metabolic control of cell growth
Current Opinion in Cell Biology · 2017 · Vol. 45 · pp. 72–82
Issam Ben‐Sahra✉(Harvard University)Brendan D. Manning✉(Harvard University)
PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancermTORC1BiologyPI3K/AKT/mTOR pathwayCell growthCell biologyMechanistic target of rapamycinSignal transductionmTORC2AnabolismMetabolic pathway
MeSH terms
Mechanistic Target of Rapamycin Complex 1AnimalsCell CycleHumansSignal TransductionProtein Serine-Threonine KinasesMultiprotein ComplexesCell ProliferationMetabolic Networks and PathwaysTOR Serine-Threonine Kinases
Funding
- Ellison Medical Foundation
- Tuberous Sclerosis Alliance
- LAM Foundation
Citations
628
FWCI
25.19
field-weighted impact
References
124
Percentile
100%
vs. same field & year
Citations per year
References
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nature Cell Biology · 2011 · 6,906 citations
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Molecular Cell · 2010 · 1,954 citations
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
Developmental Cell · 2006 · 1,398 citations
Regulation of TORC1 by Rag GTPases in nutrient response
Nature Cell Biology · 2008 · 1,317 citations
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
Cell Metabolism · 2008 · 1,365 citations
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
Molecular and Cellular Biology · 2002 · 1,171 citations
mTOR Signaling in Growth Control and Disease
Cell · 2012 · 8,373 citations
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
Molecular and Cellular Biology · 2001 · 1,245 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.