Anti-ulcer activities of ethanolic extract of Enantia chlorantha stembark in rodents

Abstract

Male adult albino rats (150 – 180g) were used for the experiment. They were randomized into six (6) groups of six (6) animals each. Food was withdrawn 24 hr and water 2 hr before the commencement of the experiment. Three models were used for this experiment (indomethacin induced ulcer, ethanol and reserpine induced ulcer). Groups 2-4 were pretreated with the extract at doses of 32.40mg/kg, 64.80 mg/kg and 96.20 mg/kg. Cimetidine was used as the standard drug. There was a progressive decline in ulcer index of the rats pre-treated with the extract. The decline was dose-dependent and statistically significant (p