Ethanol-induced gastric ulceration in rats: Protective roles of methanol and water extracts of Cyathula prostrata Linn Blume

Abstract

The study investigated gastro protective effect of methanol and water, crude extract of Cyathula prostrata against ethanol induced gastric ulcer in rats. Ulceration was induced by oral administration of absolute ethanol (1cm3/kg body weight). Wistar rats were pre-treated with Omeprazole 20mg/kg body weight, 50mg/kg, 100mg/kg and 150mg/kg per body weight of methanol and water extract separately. These extracts showed a marked deduction in the mean ulcer index parameter studied on the test animals in a dose dependence manner with a significant increase in percentage preventive index. In conclusion, it was observed that the methanol and water extract of Cyathula prostrata provides a significant anti-ulcer effect against ulcer in rats, a fact that supports the traditional use of hot water extract of the whole plants for its anti-ulcer effect.