articleTop 1% cited

Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis

Biomedicine & Pharmacotherapy · 2017 · Vol. 89 · pp. 1252–1261

Jianfeng Xue(Shanghai Sixth People's Hospital)Zhongmin Shi✉(Shanghai Sixth People's Hospital)Jian Zou(Shanghai Sixth People's Hospital)Xiaolin Li(Shanghai Sixth People's Hospital)

View via DOI Publisher page

Osteoarthritis Treatment and Mechanisms Cancer-related molecular mechanisms research Autophagy in Disease and TherapyPI3K/AKT/mTOR pathwayAutophagyProtein kinase BChemistryChondrocyteSignal transductionCell biologyCell growthRPTORMolecular biology

MeSH terms

Phosphoinositide-3 Kinase InhibitorsAnimalsAutophagyDisease Models, AnimalInflammationMaleOsteoarthritisSignal TransductionRats, Sprague-DawleyPhosphatidylinositol 3-KinasesChondrocytesProto-Oncogene Proteins c-aktRatsInterleukin-1betaTOR Serine-Threonine Kinases

Citations

417

FWCI

22.32

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

References

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis