review Open AccessTop 1% cited
Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
Acta Psychiatrica Scandinavica · 2017 · Vol. 135(5) · pp. 373–387
Cristiano A. Köhler(Universidade Federal do Ceará)Thiago Holanda Freitas(Universidade Federal do Ceará)Michaël Maes(Universidade Estadual de Londrina)Nayanna Quezado de Andrade(Universidade Federal do Ceará)C. S. Liu(Sunnybrook Health Science Centre)Brisa S. Fernandes(Universidade Federal do Rio Grande do Sul)Brendon Stubbs(King's College London)Marco Solmi(University of Padua)Nicola Veronese(University of Padua)Nathan Herrmann(Sunnybrook Health Science Centre)Charles L. Raison(University of Wisconsin–Madison)Brian J. Miller(Augusta University)Krista L. Lanctôt(Sunnybrook Health Science Centre)André F. Carvalho✉(Universidade Federal do Ceará)
Abstract
Our results further characterize a cytokine/chemokine profile associated with MDD. Future studies are warranted to further elucidate sources of heterogeneity, as well as biosignature cytokines secreted by other immune cells.
Tryptophan and brain disordersStress Responses and CortisolHealth, psychology, and well-beingMajor depressive disorderCytokineMeta-analysisChemokineInternal medicineMedicineChemokine receptorTumor necrosis factor alphaOncologyReceptor
MeSH terms
Major Depressive DisorderDepressive Disorder, MajorFemaleHumansMaleCytokinesChemokines
Funding
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Citations
1,382
FWCI
35.52
field-weighted impact
References
74
Percentile
100%
vs. same field & year
Citations per year
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References
Quantitative Synthesis in Systematic Reviews
Annals of Internal Medicine · 1997 · 2,490 citations
A Meta-Analysis of Cytokines in Major Depression
Biological Psychiatry · 2009 · 4,637 citations
Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression
Journal of Affective Disorders · 1995 · 625 citations
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Biological Psychiatry · 2009 · 3,778 citations
The file drawer problem and tolerance for null results.
Psychological Bulletin · 1979 · 8,473 citations
IL-17 and Th17 Cells
Annual Review of Immunology · 2009 · 4,745 citations
Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis
Biometrics · 2000 · 13,532 citations
Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
Psychosomatic Medicine · 2009 · 2,733 citations
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