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CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

Journal of Clinical Investigation · 2016 · Vol. 126(6) · pp. 2123–2138

Cameron J. Turtle✉(Fred Hutch Cancer Center)Laïla-Aïcha Hanafi(Fred Hutch Cancer Center)Carolina Berger(Fred Hutch Cancer Center)Theodore A. Gooley(Fred Hutch Cancer Center)Sindhu CherianMichael Hudecek(Fred Hutch Cancer Center)Daniel Sommermeyer(Fred Hutch Cancer Center)Katherine M. Melville(Fred Hutch Cancer Center)Barbara Pender(Fred Hutch Cancer Center)Tanya M Budiarto(Fred Hutch Cancer Center)Emily Robinson(Fred Hutch Cancer Center)Natalia N Steevens(Fred Hutch Cancer Center)Colette Chaney(Fred Hutch Cancer Center)Lorinda SomaXueyan ChenCecilia C.S. Yeung(University of Washington)Brent L. Wood(University of Washington)Daniel Li(Juno Therapeutics (Germany))Jianhong Cao(Fred Hutch Cancer Center)Shelly Heimfeld(Fred Hutch Cancer Center)Michael C. Jensen(Fred Hutch Cancer Center)Stanley R. Riddell(Fred Hutch Cancer Center)David G. Maloney(Fred Hutch Cancer Center)

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Abstract

R01-CA136551; Life Science Development Fund; Juno Therapeutics; Bezos Family Foundation.

CAR-T cell therapy research Immune Cell Function and InteractionCD19CD8Composition (language)ImmunologyChemistryBiologyAntigenArt

MeSH terms

AdultAgedHumansLymphocyte DepletionMiddle AgedReceptors, Antigen, T-CellPrecursor B-Cell Lymphoblastic Leukemia-LymphomaT-Lymphocyte SubsetsImmunotherapy, AdoptiveCD4-CD8 RatioDisease-Free SurvivalTumor BurdenYoung Adult

Funding

Damon Runyon Cancer Research Foundation
Gilead Sciences
Fred Hutchinson Cancer Research Center
Juno Therapeutics
National Cancer Institute

Citations

2,064

FWCI

100.86

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

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Current concepts in the diagnosis and management of cytokine release syndrome

Blood · 2014 · 2,742 citations

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Science Translational Medicine · 2014 · 2,472 citations

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

Science Translational Medicine · 2013 · 2,062 citations

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

Science Translational Medicine · 2015 · 1,707 citations

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Science Translational Medicine · 2011 · 2,388 citations

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

Leukemia · 2015 · 832 citations

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