article Open AccessTop 1% cited
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
Science Translational Medicine · 2017 · Vol. 9(399)
Donald M. O’Rourke(University of Pennsylvania)MacLean P. Nasrallah✉(University of Pennsylvania)Arati Desai✉(University of Pennsylvania)J. Joseph Melenhorst✉(University of Pennsylvania)Keith G. Mansfield✉(Novartis (United States))Jennifer J.D. Morrissette(Computational Diagnostics (United States))María Martínez-Lage(University of Pennsylvania)Steven Brem(University of Pennsylvania)Eileen Maloney(University of Pennsylvania)Angela Shen(Novartis (United States))Randi Isaacs(Novartis (United States))Suyash Mohan(University of Pennsylvania)Gabriela Plesa(University of Pennsylvania)Simon F. Lacey(University of Pennsylvania)Jean‐Marc Navenot(University of Pennsylvania)Zhaohui Zheng(University of Pennsylvania)Bruce L. Levine(University of Pennsylvania)Hideho Okada(University of California, San Francisco)Carl H. June(University of Pennsylvania)Jennifer L. Brogdon(Novartis (United States))Marcela V. Maus✉(Massachusetts General Hospital)
Abstract
A trial of autologous T cells redirected to a specific mutation in glioblastoma patients illustrates mechanisms of resistance.
CAR-T cell therapy researchNanowire Synthesis and ApplicationsVirus-based gene therapy researchGlioblastomaAntigenCancer researchMedicineMutationImmunologyBiologyGeneGenetics
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Science Translational Medicine · 2015 · 1,707 citations
T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
Science Translational Medicine · 2011 · 2,388 citations
CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients
Journal of Clinical Investigation · 2016 · 2,064 citations
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