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Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study

PLoS ONE · 2015 · Vol. 10(10) · pp. e0139981–e0139981

Daniel D. Murray✉(UNSW Sydney)Kazuo Suzuki(UNSW Sydney)Matthew Law(UNSW Sydney)Jonel Trebicka(University of Bonn)Jacquie Neuhaus(University of Minnesota)Deborah Wentworth(University of Minnesota)Margaret Johnson(Royal Free London NHS Foundation Trust)Michael J. VjechaAnthony D. Kelleher(UNSW Sydney)Sean Emery(UNSW Sydney)INSIGHT ESPRIT and SMART Study Groups

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Abstract

No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.

HIV-related health complications and treatments HIV Research and Treatment Viral-associated cancers and disordersMedicineMalignancyDiseaseImmunologyPopulationCase-control studymicroRNAInternal medicineViral loadMortality rate

MeSH terms

AdultFemaleHumansMaleMiddle AgedBiomarkersCD4-Positive T-LymphocytesHIV-1HIV InfectionsAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveMicroRNAsGenetic Association Studies