article Open AccessTop 1% cited
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Circulation Research · 2010 · Vol. 107(6) · pp. 810–817
Anna Zampetaki✉(Krankenhaus Bruneck)Stefan Kiechl(University of Cambridge)Ignat Drozdov(University of Cambridge)Peter Willeit(Krankenhaus Bruneck)Ursula Mayr(Innsbruck Medical University)Marianna Prokopi(University of Cambridge)Agnes Mayr(Krankenhaus Bruneck)Siegfried Weger(University of Cambridge)Friedrich Oberhollenzer(University of Cambridge)Enzo Bonora(University of Cambridge)Ajay M. Shah(Krankenhaus Bruneck)Johann Willeit(Innsbruck Medical University)Manuel Mayr(University of Cambridge)
Abstract
We reveal a plasma miRNA signature for DM that includes loss of endothelial miR-126. These findings might explain the impaired peripheral angiogenic signaling in patients with DM.
MicroRNA in disease regulationCancer-related molecular mechanisms researchCircular RNAs in diseasesmicroRNAType 2 diabetesOdds ratioEpigeneticsBiologyConfidence intervalProspective cohort studyInternal medicineDiabetes mellitusMicroarray
MeSH terms
AdultAgedCells, CulturedDiabetes Mellitus, Type 2Endothelium, VascularFemaleFollow-Up StudiesGenetic MarkersHumansMaleMiddle AgedProspective StudiesCohort StudiesGene Expression ProfilingMicroRNAs
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1,444
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33.67
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40
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