article Open AccessTop 1% cited
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
PLoS ONE · 2008 · Vol. 3(11) · pp. e3694–e3694
Melissa Piper Hunter(The Ohio State University)Noura Ismail(The Ohio State University)Xiaoli Zhang(The Ohio State University)Baltazar D. Aguda(The Ohio State University)Eun Joo Lee(The Ohio State University)Lianbo Yu(The Ohio State University)Tao Xiao(The Ohio State University)Jeffrey Schafer(The Ohio State University)Mei‐Ling Ting Lee(University of Maryland, College Park)Thomas D. Schmittgen(The Ohio State University)S. Patrick Nana‐Sinkam(The Ohio State University)David Jarjoura(The Ohio State University)Clay B. Marsh✉(The Ohio State University)
Abstract
This study is the first to identify and define miRNA expression in circulating plasma microvesicles of normal subjects. The data generated from this study provides a basis for future studies to determine the predictive role of peripheral blood miRNA signatures in human disease and will enable the definition of the biological processes regulated by these miRNA.
Extracellular vesicles in diseaseMicroRNA in disease regulationCancer-related molecular mechanisms researchMicrovesiclesmicroRNAPeripheral blood mononuclear cellBiologyMicrovesicleCell biologyImmune systemImmunologyGeneGenetics
MeSH terms
AdultAge FactorsFemaleGender IdentityHumansLeukocytes, MononuclearMaleMiddle AgedGene Expression ProfilingMicroRNAsExosomes
Funding
- Battelle
- National Heart, Lung, and Blood Institute
Citations
1,439
FWCI
26.76
field-weighted impact
References
65
Percentile
100%
vs. same field & year
Citations per year
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References
MicroRNAs
Cell · 2004 · 34,668 citations
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
Leukemia · 2006 · 1,623 citations
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Gynecologic Oncology · 2008 · 2,297 citations
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Nature Cell Biology · 2007 · 12,686 citations
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer
International Journal of Cancer · 2004 · 746 citations
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
Proceedings of the National Academy of Sciences · 2006 · 4,243 citations
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Cell · 2005 · 11,901 citations
Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
Leukemia · 2006 · 1,330 citations
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