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Cationic Ruthenium(II) Catalysts for Oxidative C–H/N–H Bond Functionalizations of Anilines with Removable Directing Group: Synthesis of Indoles in Water
Organic Letters · 2012 · Vol. 14(3) · pp. 764–767
Lutz Ackermann✉(University of Göttingen)Alexander V. Lygin(University of Göttingen)
Abstract
Cationic ruthenium(II) complexes enabled oxidative C-H bond functionalizations with anilines bearing removable directing groups. The C-H/N-H bond cleavages occurred most efficiently in water as a sustainable solvent and provided general access to various bioactive indoles. Mechanistic studies provided strong support for a novel reaction manifold.
Catalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling ReactionsChemistryCationic polymerizationRutheniumCatalysisOxidative phosphorylationGroup (periodic table)Medicinal chemistrySolventHalogenationCombinatorial chemistry
MeSH terms
Aniline CompoundsCatalysisCationsIndolesOxidation-ReductionRutheniumWaterMolecular Structure
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Organic & Biomolecular Chemistry · 2011 · 365 citations
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
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